Endocrine Abstracts

: A 78-year-old male with a background of renal cell carcinoma and bilateral adrenal metastasis presented with leg cramps and lethargy. He was on Prednisolone 10 mg od for immune therapy induced pneumonitis. Prior to commencing Prednisolone, he was on Dexamethasone 2 mg for 4 months for weight loss, nausea and vomiting. He underwent a Short Synacthen Test (SST) as his serum Na was low at 119 mmol/L (134–146). His SST showed a flat response with baseline and 30 minutes cor...

Case history: 81-year-old female patient admitted for fracture neck of femur was referred to endocrinology for high T4. Clinically she was euthyroid with mild thyroid eye disease.PMH: Atrial fibrillation Post CABG 30.09.15, Hypothyroidism since 1983 (started on Eltroxin by GP for weight gain and tiredness though patient never had biochemical evidence of hypothyroidism), OA of spine 2007, T2DM, Asthma.Drug history: Amioda...

Case history: 62 Year old male known to have inflammatory bowel disease, ischemic cardiomyopathy, ICD implant for sustained ventricular tachycardia was referred to endocrine clinic by the GP for thyrotoxicosis which was found on lab workup for worsening diarrhoea and tiredness.Drug historyAmiodarone 200 mg od since 2012, Bisoprolol, Eplerenone, Atorvastain and Pentasa.Investigations: FT4 48.6 pmol/l (6.5&#150...

Introduction: Discordant thyroid function tests are frequently identified in clinical practice and should raise suspicions about laboratory analytical interference.Case report: A 59 year old male was referred to Endocrine services for abnormal thyroid function tests following his recent Emergency department presentation with palpitations. His TFT (Roche) showed FT4 level was raised at 27.1 pmol/l (6.5 - 17.0), and his TSH normal at 2.57 uIU/ml (0.34 - 5....

32 year old male patient admitted to A&E with a 3 days history of confusion and generalised oedema. History from the mother revealed long standing self-neglect, poor nutrition and prolonged immobility due to abnormal painful sensation and weakness in the lower limbs. This is preceded by a post traumatic drastic change in character of the patient, with resultant agoraphobia and excess consumption of alcohol. Investigations on admission include: TSH 128 ulu/ml (0.27-4.20), T...

Background: The published data on the natural history of (presumed) non-functioning pituitary microadenomas (micro-NFAs) is possibly compromised by small sample sizes, short follow-up and inclusion of cases with other pathologies in the analyses.Objective: To clarify the long-term outcomes of micro-NFAs in a large cohort of patients.Methods: We conducted a multi-centre, retrospective, cohort study involving 22 UK endocrine departme...

Background: Large series of patients elucidating the natural history of conservatively managed non-functioning pituitary macroadenomas (macroNFPAs) and relevant prognostic factors are not available.Objectives: Clarify long-term outcomes of macroNFPAs in large cohort of patients.Methods: Multi-centre [21 UK endocrine departments-UK NFPA consortium], retrospective, cohort study of ca...